ANAL CANCER

What is anal cancer?

Cancer describes a set of diseases in which normal cells in the body, through a series of genetic changes, lose the ability to control their growth and to respect their neighbors. As cancers grow, they invade the tissues around them (local invasion). They may also spread to other locations in the body via the blood vessels or lymphatic channels where they may implant and grow (metastases). Tumors, or growths in the body, may be benign or malignant (cancerous). When they are benign they may grow but they do not spread to other locations. Malignant tumors have the ability to invade deeply and to spread (metastasize).

Anal cancer arises from the cells around the anal opening (verge) or within the anal canal (1-2 inches long) up to its junction with the rectum. Most anal cancers arise from skin cells and are called squamous cell carcinomas. Some arise from the special mucosal cells lining the upper anal canal and are called cloacogenic carcinomas. Although several other types of cancer may occur in this area, these two are the most common. They behave similarly and are treated in the same fashion. Cells that are becoming malignant but have not invaded below the surface are "pre-cancerous" (carcinoma-in-situ). This condition is called Bowen's disease.

How common is anal cancer?

Anal cancer is fairly uncommon. It accounts for about 1-2% of gastrointestinal cancers. About 3,400 new cases of anal cancer are diagnosed each year in the U.S.A., and about 500 people will die of the disease each year. This may be compared to 140,000 new cases of colorectal cancer with 50,000 deaths per year.

Who is at risk?

We do not know the exact cause of most anal cancers. But we do know that certain risk factors are linked to anal cancer. A risk factor is something that increases a person's chance of getting a disease.

• Age - Most people with anal cancer are over 50 years old.
• Anal warts - Infection with the human papilloma virus (HPV) which causes condyloma (warts) may increase the chance of developing anal cancer.
• Anal sex - Persons who participate in anal sex are at an increased risk.
• Smoking - Harmful chemicals from smoking increase the risk of most cancers including anal cancer.
• Immunosuppression - People with weakened immune systems, such as transplant patients who must take drugs to suppress their immune systems and patients with HIV (human immunodeficiency virus) infection, are at a somewhat higher risk.
• Chronic local inflammation - People with long-standing anal fistulas or open wounds are at a slightly higher risk.
• Pelvic radiation - People who have had pelvic radiation therapy for rectal, prostate, bladder or cervical cancer are at an increased risk.

Can anal cancer be prevented?

Few cancers can be totally prevented but your risk may be decreased significantly by reducing your risk factors and by getting regular checkups. Avoid anal sex and infection with HPV and HIV. Use condoms whenever having any kind of intercourse. Although condoms do not eliminate the risk of infection, they do reduce it. Stopping smoking lowers the risk of many types of cancer, including anal cancer.

What are the symptoms of anal cancer?

• Bleeding from the rectum or anus
• The feeling of a lump or mass at the anal opening
• Pain in the anal area
• Persistent or recurrent itching
• Change in bowel habits (having more or fewer bowel movements) or increased straining during a bowel movement
• Narrowing of the stools
• Discharge (mucous or pus) from the anus
• Swollen lymph nodes (glands) in the anal or groin areas.

These symptoms can also be caused by less serious conditions such as hemorrhoids but you should never assume this. If you have any of these symptoms, see your doctor.

How is anal cancer diagnosed?

If anal cancer is suspected based on your doctor’s exam, a biopsy will be performed to confirm the diagnosis. If the diagnosis of cancer is confirmed, additional tests to determine the extent of the cancer may be recommended.

How are anal cancers treated?

• surgery – an operation to remove the cancer
• radiation therapy – high-dose x-rays to kill cancer cells, and
• chemotherapy – giving drugs to kill cancer cells.

Combination therapy including radiation therapy and chemotherapy is now considered the standard treatment for most anal cancers. Occasionally a very small or early tumor may be removed surgically (local excision), with minimal damage to the anal sphincter muscles.

Will I need a colostomy?

The majority of patients treated for anal cancer will not need a colostomy. If the tumor does not respond completely to combination therapy, if it recurs after treatment, or if it is an unusual type, an abdomino-perineal resection (APR) removal of the rectum and anus and creation of a colostomy may be necessary.

What happens after treatment for anal cancer?

Follow-up care to assess the results of treatment and to check for recurrence is very important. Most anal carcinomas are effectively treated. In addition, many tumors that recur may be successfully treated if they are caught early. A careful examination by an experienced physician at regular intervals is the most important method of follow-up. Additional studies may be recommended. You should report any symptoms or problems to your doctor right away.

Conclusion

Anal cancers are unusual tumors arising from the skin or mucosa of the anal canal. As with most cancers, early detection is associated with excellent survival. Most tumors are well treated with combination chemotherapy and radiation. Recurrences may often be treated successfully. Follow the recommended screening examinations for anal and colorectal cancer and consult your doctor early when any anorectal symptoms occur.

 

© American Society of Colon and Rectal Surgeons